Prof. Nicolai Cramer Vortrag Efficiency in Catalyst Design for Asymmetric Catalysis im Raum A12.232, TU Chemnitz; Berechnungsbasierte Vorhersagen verbessern Katalysatorenauswahl

Prof. Nicolai Cramer Vortrag Efficiency in Catalyst Design for Asymmetric Catalysis im Raum A12.232, TU Chemnitz; Berechnungsbasierte Vorhersagen verbessern Katalysatorenauswahl

Folie 1

Fakultät für Naturwissenschaften Institut für Chemie Vortrag von Herrn Prof. Nicolai Cramer EPFL, SB, Institute of Chemistry and Chemical Engineering, Laboratory of Asymmetric Catalysis and Synthesis Lausanne, Switzerland lädt ein gemeinsam mit der Gesellschaft Deutscher Chemiker zum am: 22.10.2026 um: 17:00 Uhr wo: im Raum A12.232 Gäste sind herzlich willkommen! Prof. Dr. Michael Sommer Telefon: 0371 / 531 32507 E-Mail: michael.sommer@chemie.tu-chemnitz.de “Efficiency in Catalyst Design for Asymmetric Catalysisi: Rationality, Diversity, Preditability…Luck”

Fakultät für Naturwissenschaften Institut für Chemie Prof. Dr. Michael Sommer Telefon: 0371 / 531 32507 E-Mail: michael.sommer@chemie.tu-chemnitz.de Prof. Nicolai Cramer EPFL, SB, Institute of Chemistry and Chemical Engineering, Laboratory of Asymmetric Catalysis and Synthesis Lausanne, Switzerland EFFICIENCY IN CATALYST DESIGN FOR ASYMMETRIC CATALYSISI: RATIONALITY, DIVERSITY, PREDICTABILITY…LUCK? Access to robust tailored chiral ligands is of critical importance for advances in homogenous enantioselective catalysis. The design and development of novel ligand libraries is often a time-consuming and often tedious trial-and-error process. We seek to identify new privileged chiral elements / scaffolds which could be rapidly adapted and used for a broad range of reaction types. Pairing the structural data of the chiral micro environments of the catalytically active sites with computational selectivity predictions sharpens the focus on the preparation of “high potential” catalyst candidates for the library. The presentation will cover recent examples of my laboratory.[1-4] Figure 1. Streamlined access to Cpx-metal catalysts References: [1] B. Van Den Bossche, N. Cramer, J. Am. Chem. Soc. 2026, 148, 3775-3787. [2] Y.-X. Cao, A.-S. Chauvin, S. Tong, L. Alama, N. Cramer, Nat. Catal. 2025, doi: 10.1038 /s41929-025-01352-3. [3] L. K. Verdhi, M. D. Wodrich, N. Cramer, J. Am. Chem. Soc. 2025, 147, 15041. [4] Y. S. Ye, A. Laverny, M. D. Wodrich, R. Laplaza, F. Fadaei-Tirani, R. Scopelliti, C. Corminboeuf, N. Cramer, J. Am. Chem. Soc. 2024, 146, 34786.